Generic Zaroxolyn by Zydus available discount pricing through Global Pharmacy Plus and save up to 80% off what you would pay in the US pharmacies. Zytanix used to reduce the swelling and fluid retention caused by heart failure or kidney disease. The Zydus version of this drug is called Zytanix / Metolazone is the equivalent to the brand name Zaroxolyn. What is Zaroxolyn is used for? Metolazone, is used to reduce the swelling and fluid retention caused by heart failure or kidney disease. It also is used alone or with other medications to treat high blood pressure. Metolazone is in a class of medications called diuretics ('water pills'). It causes the kidneys to reduce the amount of water and salt in the body by increasing the amount of urine. Generic Zaroxolyn is available only by prescription only. Metolazone may also be used for other medical uses as directed by your doctor.